Effects of Bacteriophages on Melanoma Migration
Author Information
Author(s): Dąbrowska Krystyna, Skaradziński Grzegorz, Jończyk Paulina, Kurzępa Aneta, Wietrzyk Joanna, Owczarek Barbara, Żaczek Maciej, Świtała-Jeleń Kinga, Boratyński Janusz, Poźniak Gryzelda, Maciejewska Magdalena, Górski Andrzej
Primary Institution: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Hypothesis
Can bacteriophage preparations inhibit the migration of melanoma cells?
Conclusion
Bacteriophage preparations T4 and HAP1 can inhibit the migration of human and mouse melanoma cells.
Supporting Evidence
- T4 and HAP1 bacteriophages inhibited the migration of B16 mouse melanoma by 34% and 36%, respectively.
- Human melanoma migration was decreased by 31% with T4 bacteriophage.
- HAP1 phage inhibited Hs294T human melanoma migration by 48%.
Takeaway
Bacteriophages, which are viruses that attack bacteria, can help stop melanoma cells from moving around in the body.
Methodology
The study involved in vitro migration assays of melanoma cells treated with bacteriophage preparations.
Limitations
The variability in the migration assay results made analysis challenging.
Statistical Information
P-Value
p = 0.0235, p = 0.0164, p = 0.0008, p = 0.0423, p = 0.0859, p = 0.0407
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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