Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera
Author Information
Author(s): Sougata Ghosh, Mehul Ahire, Sumersing Patil, Amit Jabgunde, Dusane Meenakshi Bhat, Bimba N. Joshi, Karishma Pardesi, Sanjay Jachak, Dilip D. Dhavale, Balu A. Chopade
Primary Institution: University of Pune
Hypothesis
Can Gnidia glauca and Dioscorea bulbifera effectively inhibit α-amylase and α-glucosidase enzymes?
Conclusion
Both Gnidia glauca and Dioscorea bulbifera show significant inhibitory effects on key enzymes related to diabetes management.
Supporting Evidence
- Petroleum ether extract of G. glauca flower showed 78.56% inhibition of α-amylase.
- D. bulbifera exhibited significant inhibition against murine pancreatic glucosidase.
- Ethyl acetate extract of D. bulbifera showed 99.6% inhibition of α-glucosidase.
Takeaway
This study found that two plants, Gnidia glauca and Dioscorea bulbifera, can help lower blood sugar by blocking certain enzymes.
Methodology
The study involved extracting plant materials and testing their inhibitory effects on α-amylase and α-glucosidase enzymes using various assays.
Limitations
The study primarily focused on in vitro results, and further in vivo studies are needed to confirm the findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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