Glutathione S-transferase expressions in epilepsy patients
Author Information
Author(s): Shang Wei, Liu Wei-Hong, Zhao Xiu-He, Sun Qin-Jian, Bi Jian-Zhong, Chi Zhao-Fu
Primary Institution: Second Hospital of Shandong University
Hypothesis
Higher levels of GSTs in brain, especially in brain-blood barrier may result in poor intraparenchymal accumulation of AEDs, and lead to medical intractability.
Conclusion
High levels of GST-π in endothelial cells and glial cells/astrocyte correlate to medical intractable epilepsy, suggesting that GST-π contributes to resistance to AED treatment.
Supporting Evidence
- GST-α expression was not seen in any cortex specimens.
- 63% of control and 53% of intractable epileptic specimens showed GST-μ immunoreactivity.
- 50% of control patients and 66% of epileptic patients were GST-π positive.
Takeaway
This study found that a protein called GST-π is more common in the brains of people with hard-to-treat epilepsy, which might make their medicine less effective.
Methodology
The study used immunohistochemistry to examine GST expressions in brain tissues from 32 intractable epileptic patients and 8 non-epileptic controls.
Participant Demographics
32 epileptic patients (18 male, 14 female, aged 8 to 43 years) and 8 non-epileptic controls.
Statistical Information
P-Value
p < 0.01
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
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