Genetic Factors in Reading Disabilities and Language Impairment
Author Information
Author(s): Scerri Tom S., Morris Andrew P., Buckingham Lyn-Louise, Newbury Dianne F., Miller Laura L., Monaco Anthony P., Bishop Dorothy V.M., Paracchini Silvia
Primary Institution: Wellcome Trust Centre for Human Genetics, University of Oxford, UK
Hypothesis
Do candidate genes for reading disability (RD) and specific language impairment (SLI) affect cognitive traits?
Conclusion
The study found that KIAA0319 and DCDC2 are associated with reading abilities, while CMIP is also implicated in reading processes.
Supporting Evidence
- DCDC2 is specifically associated with reading disability.
- KIAA0319 and CMIP are associated with reading skills across the ability range.
- Associations were stronger when including individuals with comorbidity.
- MRPL19/C2ORF3 was not supported as a locus involved in reading abilities.
Takeaway
Some genes can make it harder for kids to read or understand language, and this study looked at how those genes work together.
Methodology
The study analyzed common risk variants in a cohort of children using genetic association analysis.
Potential Biases
Potential bias due to the exclusion of individuals with comorbid conditions in some analyses.
Limitations
The study may not generalize to populations outside of the ALSPAC cohort.
Participant Demographics
Children born in southwest England in the early 1990s.
Statistical Information
P-Value
p < .0023
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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