Study of Serum Proteins in Ovarian Cancer Patients
Author Information
Author(s): Chen Yeng, Lim Boon-Kiong, Peh Suat-Cheng, Abdul-Rahman Puteri Shafinaz, Hashim Onn Haji
Primary Institution: University of Malaya
Hypothesis
The study investigates the expression of high abundance acute-phase proteins in patients with epithelial and germ line ovarian carcinoma.
Conclusion
Patients with EOCa and GOCa demonstrated distinctive aberrant expression of serum and tissue high abundance acute-phase proteins compared to negative control women.
Supporting Evidence
- Enhanced expression of clusterin, α1-antitrypsin, haptoglobin, and leucine rich glycoprotein was detected in all patients.
- The levels of α1-antichymotrypsin was only enhanced in EOCa patients.
- GOCa patients were characterized by elevated levels of ceruloplasmin but lower levels of α2-HS glycoprotein.
Takeaway
This study looked at proteins in the blood of women with ovarian cancer and found that they have different levels of certain proteins compared to healthy women.
Methodology
The study used a gel-based proteomic approach to analyze serum samples and validated findings with ELISA and immunohistochemical staining.
Limitations
The study's controls were serum samples from normal healthy individuals, which may not fully account for inflammation effects.
Participant Demographics
29 patients with EOCa (ages 24 to 65) and 13 GOCa patients (ages 12 to 24).
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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