HERV-K(HML-2) Signal Peptide and Its Unique Functions
Author Information
Author(s): Alessia Ruggieri, Esther Maldener, Marlies Sauter, Nikolaus Mueller-Lantzsch, Eckart Meese, Oliver T. Fackler, Jens Mayer
Primary Institution: Department of Human Genetics, Medical Faculty, University of Saarland, Homburg, Germany
Hypothesis
What are the biological properties of the HERV-K(HML-2) signal peptide compared to Rec?
Conclusion
The HERV-K(HML-2) signal peptide is a distinct protein that may play a role in immune evasion in germ cell tumors.
Supporting Evidence
- HERV-K(HML-2) signal peptide is less stable than Rec and is subjected to proteasomal degradation.
- HERV-K(HML-2) signal peptide does not shuttle between the nucleus and cytoplasm.
- HERV-K(HML-2) signal peptide lacks RNA export activity, unlike Rec.
Takeaway
The study found a new protein from a virus that might help cancer cells hide from the immune system.
Methodology
Biochemical analysis and confocal microscopy were used to study the properties and localization of the HERV-K(HML-2) signal peptide.
Limitations
The specific role of the HERV-K(HML-2) signal peptide in human biology remains unclear.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website