Infection of Rhesus Macaques with HCoV-NL63
Author Information
Author(s): Ronald Dijkman, H. Lie Mulder, Lynne Rumping, Ilse Kraaijvanger, Martin Deijs, Maarten F. Jebbink, Ernst J. Verschoor, Lia van der Hoek
Primary Institution: Academic Medical Centre (AMC), University of Amsterdam
Hypothesis
Can rhesus macaques encounter natural infections with HCoV-NL63?
Conclusion
Rhesus macaques likely experience natural infections with HCoV-NL63 or a closely related virus.
Supporting Evidence
- Five out of 32 serum samples showed high levels of antibodies to HCoV-NL63.
- Three monkeys showed a steep rise in antibody levels over time.
- Antibody responses were specific to HCoV-NL63 and not to HCoV-229E.
Takeaway
This study found that some monkeys got sick from a virus similar to one that makes people cough and sneeze.
Methodology
The study examined antibody levels in serum samples from rhesus macaques over several years to determine exposure to HCoV-NL63.
Limitations
The study could not confirm the specific virus responsible for the antibody response due to lack of additional samples.
Participant Demographics
Rhesus macaques with Indian, Burmese, or Chinese genetic backgrounds.
Digital Object Identifier (DOI)
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