Endometriosis and Ovarian Cancer: A Systematic Review
Author Information
Author(s): Sayasneh Ahmad, Tsivos Dimitris, Crawford Robin
Primary Institution: The Rosie Hospital, Cambridge University Hospital NHS Trust
Hypothesis
To evaluate the literature for evidence of a correlation between endometriosis and ovarian cancer.
Conclusion
There is increased risk of ovarian cancers, specifically endometrioid and clear-cell carcinoma, in women with endometriosis, but more evidence is needed before changing treatment approaches.
Supporting Evidence
- Seven out of the eight studies included in the review showed an increased risk of ovarian cancer.
- The effect size ranged between 1.32 and 1.9.
- A causative relationship between endometriosis and ovarian cancer cannot be confirmed.
- There is increasing evidence on the role of genetic mutations in ovarian clear-cell and endometrioid carcinoma developing from endometriosis.
Takeaway
Women with endometriosis might have a higher chance of getting certain types of ovarian cancer, but it's not a sure thing.
Methodology
A systematic review of English language literature from MEDLINE and EMBASE databases, focusing on studies from January 1985 to August 2010.
Potential Biases
Selection bias due to exclusion of certain studies and reliance on self-reported data.
Limitations
The studies included had modest effect sizes and potential biases in selection and reporting.
Participant Demographics
Women of reproductive age, with a focus on those with endometriosis.
Statistical Information
Confidence Interval
95% CI
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website