GC Content in Fish Genomes
Author Information
Author(s): Melodelima Christelle, Gautier Christian
Primary Institution: Laboratoire d'Ecologie Alpine, UMR CNRS 5553, Université J. Fourier, France
Hypothesis
Can isochore properties be detected in the genomes of teleost fishes despite their homogeneity in GC content?
Conclusion
The study found that GC content is a reliable indicator of isochore presence in fish genomes, revealing a mosaic structure similar to that in mammals.
Supporting Evidence
- The study confirmed the presence of GC segmentation in the genomes of T. nigroviridis and D. rerio.
- A correlation was found between GC content and gene density in the analyzed fish genomes.
- The segmentation method used was able to detect isochore-like structures in the fish genomes.
Takeaway
This study shows that even in fish, which seem to have a uniform GC content, there are still areas in their DNA that behave like isochore regions found in mammals.
Methodology
Hidden Markov models were used to analyze the genomes of T. nigroviridis and D. rerio to identify GC segmentation.
Limitations
The study primarily focuses on two fish species, which may limit the generalizability of the findings to other teleosts.
Statistical Information
P-Value
p<2.10-16
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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