MicroRNA Roles in Polycystic Kidney Disease
Author Information
Author(s): Pandey Priyanka, Brors Benedikt, Srivastava Prashant K, Bott Andrea, Boehn Susanne NE, Groene Herrmann-Josef, Gretz Norbert
Primary Institution: Medical Research Center, University Hospital Mannheim, Germany
Hypothesis
This study investigates the role of microRNAs in the regulation of gene expression in polycystic kidney disease (PKD).
Conclusion
The study suggests that microRNAs play an important role in regulating pathways involved in polycystic kidney disease.
Supporting Evidence
- 935 genes were differentially regulated between PKD and control animals.
- 30 miRNAs were differentially regulated in PKD rats.
- miR-21 was the only up-regulated miRNA, while 29 others were down-regulated.
Takeaway
Researchers looked at tiny molecules called microRNAs to see how they affect kidney disease in rats. They found that these molecules might help control how genes work in the disease.
Methodology
The study used microarray analysis to profile mRNA and miRNA expression in PKD and control rats.
Participant Demographics
Inbred homozygous unaffected and heterozygous affected Han:SPRD rats were used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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