Linkage and Association of MYOC Polymorphisms with High Myopia in a Chinese Population
Author Information
Author(s): Tang Wing Chun, Yip Shea Ping, Lo Ka Kin, Ng Po Wah, Choi Pik Shan, Lee Sau Yin, Yap Maurice K.H.
Primary Institution: The Hong Kong Polytechnic University
Hypothesis
Polymorphisms in and around the MYOC gene may play a role in myopia susceptibility.
Conclusion
The study found a significant association between MYOC polymorphisms and high myopia in a Chinese population.
Supporting Evidence
- FBAT analysis showed linkage and association with high myopia for two microsatellites and two SNPs.
- NGA17 at the promoter was significant under an additive model (p=0.0084).
- NGA19 showed significant results under both additive (p=0.0172) and dominant (p=0.0053) models.
- SNP rs2421853 exhibited both linkage and association under additive (p=0.0009) and dominant/recessive (p=0.0041) models.
- SNP rs235858 was significant under additive (p=4.0E-6) and dominant/recessive (p=2.5E-5) models.
Takeaway
This study looked at families in Hong Kong to see if certain genes are linked to being very nearsighted, and they found some strong connections.
Methodology
A family-based association study was conducted with 162 Chinese nuclear families, genotyping two MYOC microsatellites and five SNPs.
Potential Biases
Potential bias due to population stratification was minimized by using a family-based design.
Limitations
The study may not be generalizable beyond the Chinese population and was limited to specific genetic markers.
Participant Demographics
The study involved 162 nuclear families of Chinese descent, with a mean age of myopic offspring being 24.9 years and 65.7% female.
Statistical Information
P-Value
p=0.0009 for rs2421853 and p=4.0E-6 for rs235858
Confidence Interval
1.222-2.308 for rs2421853 and 2.301-6.717 for rs235858
Statistical Significance
p<0.05
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