The Role of p66Shc Protein in Aging and Cell Function
Author Information
Author(s): Suski Jan M., Karkucinska-Wieckowska Agnieszka, Lebiedzinska Magdalena, Giorgi Carlotta, Szczepanowska Joanna, Szabadkai Gyorgy, Duszynski Jerzy, Pronicki Maciej, Pinton Paolo, Wieckowski Mariusz R.
Primary Institution: Nencki Institute of Experimental Biology
Hypothesis
The p66Shc protein regulates life span in mammals and influences oxidative stress responses.
Conclusion
The study highlights the significant role of p66Shc in aging and its impact on reactive oxygen species production and detoxification.
Supporting Evidence
- p66Shc is implicated in the aging process and various oxidative stress-related diseases.
- Mice lacking p66Shc show increased lifespan without pathological consequences.
- p66Shc influences mitochondrial function and ROS production.
- Antioxidant supplementation can improve cell function and delay aging effects.
Takeaway
p66Shc is a protein that helps control how cells respond to stress and can affect how long they live. When it's not working right, it can lead to problems like aging and diseases.
Methodology
The article reviews existing studies on p66Shc and its effects on aging and oxidative stress in fibroblasts.
Limitations
The review is based on existing literature and may not include all recent findings.
Digital Object Identifier (DOI)
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