Anti-inflammatory and Immune Therapy for Alzheimer's Disease: Current Status and Future Directions
2007

Anti-inflammatory and Immune Therapy for Alzheimer's Disease

publication Evidence: moderate

Author Information

Author(s): Douglas Walker, Lih-Fen Lue

Primary Institution: Sun Health Research Institute

Hypothesis

Is inhibiting inflammation a valid therapeutic target for treating Alzheimer's disease?

Conclusion

Current anti-inflammatory treatments have not shown effectiveness in clinical trials for Alzheimer's disease.

Supporting Evidence

  • Patients taking non-steroidal anti-inflammatory drugs had a lower risk of developing Alzheimer's disease.
  • Clinical trials of anti-inflammatories have not shown effectiveness.
  • Animal studies with Aβ vaccines have shown enhanced amyloid removal.

Takeaway

This study looks at whether reducing inflammation can help treat Alzheimer's disease, but so far, the treatments haven't worked well in tests.

Methodology

The review examines various studies and trials related to anti-inflammatory treatments for Alzheimer's disease.

Potential Biases

Some earlier studies may have selection biases.

Limitations

Clinical trials of anti-inflammatories have generally been negative in preventing cognitive decline.

Participant Demographics

The review discusses various studies involving Alzheimer's patients, but specific demographics are not detailed.

Digital Object Identifier (DOI)

10.2174/157015907782793667

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