Anti-inflammatory and Immune Therapy for Alzheimer's Disease
Author Information
Author(s): Douglas Walker, Lih-Fen Lue
Primary Institution: Sun Health Research Institute
Hypothesis
Is inhibiting inflammation a valid therapeutic target for treating Alzheimer's disease?
Conclusion
Current anti-inflammatory treatments have not shown effectiveness in clinical trials for Alzheimer's disease.
Supporting Evidence
- Patients taking non-steroidal anti-inflammatory drugs had a lower risk of developing Alzheimer's disease.
- Clinical trials of anti-inflammatories have not shown effectiveness.
- Animal studies with Aβ vaccines have shown enhanced amyloid removal.
Takeaway
This study looks at whether reducing inflammation can help treat Alzheimer's disease, but so far, the treatments haven't worked well in tests.
Methodology
The review examines various studies and trials related to anti-inflammatory treatments for Alzheimer's disease.
Potential Biases
Some earlier studies may have selection biases.
Limitations
Clinical trials of anti-inflammatories have generally been negative in preventing cognitive decline.
Participant Demographics
The review discusses various studies involving Alzheimer's patients, but specific demographics are not detailed.
Digital Object Identifier (DOI)
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