Understanding Tetherin's Role in Virus Inhibition
Author Information
Author(s): Anna Le Tortorec, Suzanne Willey, Stuart J. D. Neil
Primary Institution: King’s College London School of Medicine
Hypothesis
How does tetherin inhibit the release of enveloped viruses and what are the viral countermeasures against it?
Conclusion
Tetherin effectively restricts the release of various enveloped viruses, but many viruses have developed specific countermeasures to evade this restriction.
Supporting Evidence
- Tetherin inhibits the release of diverse enveloped viruses by targeting their lipid membranes.
- Viral proteins like Vpu and Env counteract tetherin's effects to facilitate virus release.
- Tetherin's evolutionary pressure has led to the development of viral countermeasures.
Takeaway
Tetherin is like a security guard that stops viruses from leaving a cell, but some viruses have found ways to sneak past it.
Methodology
This review summarizes the molecular mechanisms of tetherin's antiviral action and the countermeasures employed by various viruses.
Limitations
The review primarily focuses on primate lentiviruses and may not cover all enveloped viruses.
Digital Object Identifier (DOI)
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