Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives
1998
Understanding Multidrug-Resistant Tuberculosis
publication
Evidence: high
Author Information
Author(s): Ashok Rattan, Awdhesh Kalia, Nishat Ahmad
Primary Institution: All India Institute of Medical Sciences, New Delhi, India
Hypothesis
What are the genetic mechanisms behind multidrug resistance in Mycobacterium tuberculosis?
Conclusion
Mutations in specific genes are primarily responsible for multidrug resistance in tuberculosis.
Supporting Evidence
- Multidrug-resistant strains of Mycobacterium tuberculosis threaten tuberculosis control efforts.
- Resistance is primarily due to mutations in drug target genes.
- Delayed recognition of drug resistance contributes to outbreaks.
- Proper treatment regimens can cure tuberculosis if followed correctly.
Takeaway
Some germs that cause tuberculosis can become super strong and not get killed by medicine. Scientists are trying to understand why this happens so they can help people get better.
Methodology
The review examines genetic and molecular studies on drug resistance mechanisms in Mycobacterium tuberculosis.
Limitations
The study does not provide new experimental data but reviews existing literature.
Want to read the original?
Access the complete publication on the publisher's website