Growth Hormone Receptor Polymorphism in Turkish Adults
Author Information
Author(s): Baş Firdevs, Keleşoğlu Fatih, Timirci Özlem, Kabataş Eryılmaz Sema, Bozkurt Nilüfer, Küçükemre Aydın Banu, Bundak Rüveyde, İsbir Turgay, Darendeliler Feyza
Primary Institution: Istanbul University
Hypothesis
The study aimed to evaluate the distribution of d3/fl-GHR polymorphism in a Turkish population.
Conclusion
The distribution of GHR polymorphism in the Turkish population is similar to that in European populations, with no significant correlations to height or other characteristics except for higher IGFBP-3 levels in the fl/d3 group.
Supporting Evidence
- The distribution of GHR exon 3 genotypes was 35% for fl/fl, 39% for fl/d3, and 26% for d3/d3.
- There were no differences in height SDS and BMI SDS among the three d3/fl-GHR genotype groups.
- IGFBP-3 SDS was significantly higher in the fl/d3 group compared to the fl/fl group.
Takeaway
This study looked at a gene that affects growth hormone response in Turkish adults and found that the gene variations are similar to those in Europeans.
Methodology
The study involved 477 healthy adults, analyzing their GHR exon 3 genotypes using multiplex PCR and measuring IGF-1 and IGFBP-3 levels.
Limitations
The study did not include individuals who had received GH therapy or other anabolic drugs.
Participant Demographics
477 healthy adults (54 females, 423 males) with a mean age of 31.1 years.
Statistical Information
P-Value
0.022
Statistical Significance
p=0.022
Digital Object Identifier (DOI)
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