HER-2/neu in Esophageal Cancer
Author Information
Author(s): Sato-Kuwabara Yukie, Neves José I, Fregnani José HTG, Sallum Rubens A, Soares Fernando A
Primary Institution: Hospital AC Camargo
Hypothesis
The study aims to verify the presence of HER-2/neu gene amplification using FISH and correlate the results with immunohistochemical expression and clinical-pathological findings.
Conclusion
HER-2/neu gene amplification is an important prognostic indicator in esophageal squamous cell carcinoma.
Supporting Evidence
- 63.2% of cases were negative for c-erbB-2 expression.
- 19.1% of cases showed HER-2/neu gene amplification.
- All cases with gene amplification were positive (3+) by immunohistochemistry.
Takeaway
This study looked at a type of cancer called esophageal squamous cell carcinoma and found that a specific gene, HER-2/neu, can help predict how well patients will do.
Methodology
The study evaluated 199 ESCC cases using Tissue Microarray (TMA) technique, FISH for gene amplification, and immunohistochemistry for protein expression.
Limitations
The study had a low number of cases suitable for FISH analysis and variability in previous studies on HER-2/neu amplification.
Participant Demographics
{"gender":{"male":161,"female":38},"ethnicity":{"Caucasian":148,"Not Caucasian":42,"No data available":9},"age":{"mean":57,"range":"37-80"}}
Statistical Information
P-Value
0.003
Statistical Significance
p = 0.003
Digital Object Identifier (DOI)
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