Lactococcus lactis NCC 2287 Reduces Allergic Symptoms in Mice
Author Information
Author(s): Adrian W. Zuercher, Marietta Weiss, Sébastien Holvoet, Mireille Moser, Hélène Moussu, Laurence van Overtvelt, Stéphane Horiot, Philippe Moingeon, Sophie Nutten, Guénolée Prioult, Anurag Singh, Annick Mercenier
Primary Institution: Nestle Research Center
Hypothesis
Can Lactococcus lactis NCC 2287 alleviate food allergic manifestations in sensitized mice?
Conclusion
Lactococcus lactis NCC 2287 shows potential as a probiotic strain for managing allergic symptoms in sensitized mice.
Supporting Evidence
- Lactococcus lactis NCC 2287 reduced allergic scores in sensitized mice during the management phase.
- The strain did not show preventive effects when administered before sensitization.
- IL-13 levels were significantly decreased in the ileum of treated mice.
Takeaway
This study found that a specific probiotic can help reduce allergy symptoms in mice that are already allergic, but it doesn't help prevent allergies from developing in the first place.
Methodology
BALB/c mice were sensitized with ovalbumin and cholera toxin, then treated with Lactococcus lactis NCC 2287 during the management phase after sensitization.
Potential Biases
Potential bias in the selection of the probiotic strain and the specific model used.
Limitations
The study only tested one strain of probiotic and focused on a specific model of food allergy.
Participant Demographics
Female BALB/c mice, six weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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