Recurrence of Congenital Heart Disease in Pregnant Women with Familial Risk
Author Information
Author(s): Vlasta Fesslova, Jelena Brankovic, Faustina Lalatta, Laure Villa, Valerio Meli, Luciane Piazza, Cristian Ricci
Primary Institution: Policlinico San Donato IRCCS
Hypothesis
What is the recurrence rate of congenital heart disease (CHD) in pregnancies with a familial history of CHD?
Conclusion
The study found a higher recurrence rate of congenital heart disease than previously published data.
Supporting Evidence
- The total recurrence rate of CHD was found to be 3.98%.
- Recurrence rates varied based on the number of affected relatives, with higher rates in cases with multiple familial risks.
- Exact concordance of CHD was found in 21.5% of cases.
Takeaway
If someone in your family has heart problems, there's a chance that babies in the family might have similar heart issues too.
Methodology
The study analyzed 1634 pregnancies from women with a familial history of CHD using fetal echocardiography and compared findings with postnatal outcomes.
Potential Biases
Potential bias due to the exclusion of certain cases and reliance on familial history.
Limitations
The study only included cases with known follow-up and excluded mothers with certain conditions.
Participant Demographics
1483 women with a familial history of CHD were included.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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