Epigenetic Signature in Prostate Carcinogenesis
Author Information
Author(s): Ke Xi-Song, Qu Yi, Rostad Kari, Li Wen-Cheng, Lin Biaoyang, Halvorsen Ole Johan, Haukaas Svein A., Jonassen Inge, Petersen Kjell, Goldfinger Naomi, Rotter Varda, Akslen Lars A., Oyan Anne M., Kalland Karl-Henning
Primary Institution: The Gade Institute, University of Bergen, Bergen, Norway
Hypothesis
Dysregulated genes in prostate cancer contain a distinct pattern of H3K4me3 and H3K27me3.
Conclusion
The study identifies an H3K4me3/H3K27me3 epigenetic signature associated with prostate carcinogenesis.
Supporting Evidence
- Genome-wide profiling revealed distinct patterns of histone modifications in prostate cancer cells.
- Changes in H3K4me3 and H3K27me3 were linked to differential gene expression.
- Epigenetic switches were associated with the activation of oncogenes and repression of tumor suppressor genes.
Takeaway
This study shows that changes in certain chemical marks on DNA can help us understand how prostate cancer develops.
Methodology
The study used chromatin immunoprecipitation coupled with whole genome promoter microarray techniques to profile histone modifications.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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