No link between TNFRSF1B gene variants and type 2 diabetes in North Indians
Author Information
Author(s): Tabassum Rubina, Mahajan Anubha, Chauhan Ganesh, Dwivedi Om Prakash, Dubey Himanshu, Sharma Vasudha, Kundu Bratashree, Ghosh Saurabh, Tandon Nikhil, Bharadwaj Dwaipayan
Primary Institution: CSIR-Institute of Genomics and Integrative Biology, Delhi, India
Hypothesis
Are TNFRSF1B gene variants associated with type 2 diabetes in Indo-European individuals from North India?
Conclusion
The study found no significant association between TNFRSF1B variants and type 2 diabetes in the studied population.
Supporting Evidence
- The study analyzed seven SNPs in TNFRSF1B among 4,200 subjects.
- Initial phase showed nominal associations for three SNPs with type 2 diabetes.
- Replication analysis did not confirm any significant associations.
Takeaway
Researchers looked at a gene to see if it was linked to diabetes in people from North India, but they found no connection.
Methodology
The study involved a two-phase association analysis of seven SNPs in TNFRSF1B among 4,200 Indo-European subjects, including both type 2 diabetes patients and control subjects.
Limitations
The study did not replicate the initial findings in a second population, which may indicate population heterogeneity.
Participant Demographics
The study included 4,200 unrelated Indo-European subjects, with 2,120 patients with type 2 diabetes and 2,080 non-diabetic controls.
Statistical Information
P-Value
P < 0.05 for initial associations; no significant p-values in replication.
Confidence Interval
95%CI 1.03-1.37 for increased susceptibility haplotype; 95%CI 0.72-0.95 for protective haplotype.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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