TKTL1 Modulation in Colorectal Cancer
Author Information
Author(s): Diaz-Moralli Santiago, Tarrado-Castellarnau Miriam, Alenda Cristina, Castells Antoni, Cascante Marta
Primary Institution: Institut de Biomedicina at Universitat de Barcelona
Hypothesis
The study aims to correlate TKTL1 expression with tumor stage, probability of tumor recurrence, and survival in colorectal cancer patients.
Conclusion
The study found that TKTL1 expression is significantly higher in stage III tumors and decreases with metastasis, suggesting its role in tumor progression.
Supporting Evidence
- TKTL1 expression was highest in stage III tumors.
- Significant decrease in TKTL1 expression was observed in metastatic tumors.
- TKTL1 expression correlates with lymph-node involvement in colon cancer.
Takeaway
This study shows that a protein called TKTL1 is important for understanding how colorectal cancer grows and spreads.
Methodology
Immunohistochemistry was used to analyze TKTL1 expression in tumor tissues from colorectal cancer patients.
Limitations
The study's sample size is relatively small, and the correlation between TKTL1 expression and survival was not significant in untreated patients.
Participant Demographics
46 men and 17 women, average age 70 years.
Statistical Information
P-Value
0.000008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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