Mannose-binding lectin deficiency and eosinophilic meningoencephalitis in children
Author Information
Author(s): Padilla-Docal Bárbara, Dorta-Contreras Alberto J, Bu-Coifiu-Fanego Raisa, Martínez-Alderete René H, de Paula-Almeida Olga Susana, Reiber Hansotto, Jensenius Jens Christian
Primary Institution: Faculty of Medical Sciences, 'Dr Miguel Enriquez' Central Laboratory of Cerebrospinal Fluid (LABCEL), Havana Medical Sciences University, Cuba
Hypothesis
Is there an association between mannose-binding lectin deficiency and eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis in children?
Conclusion
This study reports the first known cases of mannose-binding lectin deficiency associated with eosinophilic meningoencephalitis in children.
Supporting Evidence
- All three patients had low levels of mannose-binding lectin.
- The patients exhibited symptoms typical of eosinophilic meningoencephalitis.
- The study highlights the potential role of mannose-binding lectin in the immune response to parasitic infections.
Takeaway
Three boys got sick from a brain infection caused by a parasite, and they all had low levels of a protein that helps fight infections.
Methodology
Serum levels of immunoglobulins and mannose-binding lectin were measured using various immunoassays.
Limitations
The study is based on a small number of cases, which may limit the generalizability of the findings.
Participant Demographics
Three Caucasian boys aged 5, 6, and 10 years.
Digital Object Identifier (DOI)
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