Regulators of HIV-1 Reverse Transcription
Author Information
Author(s): Warren Kylie, Warrilow David, Meredith Luke, Harrich David
Primary Institution: Queensland Institute of Medical Research
Hypothesis
The synthesis of HIV-1 proviral DNA from the viral RNA genome during reverse transcription requires host factors.
Conclusion
Cellular proteins play significant roles in facilitating or hindering the reverse transcription process of HIV-1.
Supporting Evidence
- HIV-1 reverse transcriptase interacts with various cellular proteins that influence reverse transcription.
- Cellular factors such as INI1 and HDAC1 are packaged in HIV-1 virions and are essential for viral replication.
- HuR and AKAP149 directly interact with HIV-1 reverse transcriptase, affecting its activity.
Takeaway
HIV-1 needs help from the host's own proteins to make copies of its DNA from its RNA, and some of these proteins can help while others can make it harder.
Methodology
This review discusses various cellular factors that interact with HIV-1 reverse transcriptase and integrase, affecting the reverse transcription process.
Limitations
The review does not provide experimental data but summarizes findings from various studies.
Digital Object Identifier (DOI)
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