Effect of Type-I Interferon on Retroviruses
Author Information
Author(s): Gómez-Lucía Esperanza, Collado Victorio M., Miró Guadalupe, Doménech Ana
Primary Institution: Departamento de Sanidad Animal, Facultad Veterinaria, Universidad Complutense, Madrid, Spain
Hypothesis
Type-I interferons play an important role in the innate immune response to retroviruses.
Conclusion
Type-I interferons can control retroviral infections, but their continuous presence may also overstimulate the immune system and lead to negative effects.
Supporting Evidence
- Type-I interferons are effective in controlling in vivo retroviral infections.
- Continuous presence of type-I interferons may lead to immune system overstimulation.
- Some retroviruses have mechanisms to evade the effects of type-I interferons.
Takeaway
Type-I interferons help fight off certain viruses, but too much of them can actually make things worse for the body.
Limitations
The effects of type I interferons on retroviruses are not fully understood and can vary depending on the virus and the host's immune response.
Digital Object Identifier (DOI)
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