Design and Application of Target-Focused Compound Libraries
Author Information
Author(s): Harris C. John, Hill Richard D, Sheppard David W, Slater Martin J, Stouten Pieter F.W
Primary Institution: BioFocus
Hypothesis
How can target-focused compound libraries be effectively designed and applied in drug discovery?
Conclusion
Well-designed, target-focused libraries yield higher hit rates and more efficient drug discovery compared to diverse collections.
Supporting Evidence
- Target-focused libraries are designed to interact with specific protein targets.
- These libraries can lead to higher hit rates compared to diverse compound collections.
- Focused libraries can be developed using structural data or chemogenomic models.
Takeaway
This study shows that libraries of compounds designed to target specific proteins can help find new drugs faster and more effectively.
Methodology
The article discusses various design strategies for target-focused compound libraries, including the use of structural data and chemogenomic models.
Limitations
The effectiveness of the libraries may depend on the availability of structural data for the target proteins.
Digital Object Identifier (DOI)
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