Codon Bias and Evolutionary Biology
Author Information
Author(s): Hudson Nicholas J., Gu Quan, Nagaraj Shivashankar H., Ding Yong-Sheng, Dalrymple Brian P., Reverter Antonio
Primary Institution: CSIRO Livestock Industries, Queensland Bioscience Precinct, St. Lucia, Brisbane, Queensland, Australia
Hypothesis
Differences in codon bias may play an evolutionary role in the genome-wide codon bias of six species.
Conclusion
Extreme codon bias is associated with functionally related proteins and may reflect evolutionary adaptations in different lineages.
Supporting Evidence
- Extreme codon bias was found in genes related to hair in mammals.
- Human genes showed stronger codon bias for DNA-binding transcription factors compared to yeast.
- Arabidopsis thaliana exhibited extreme codon bias in genes for cell wall formation.
- Gallus gallus had strong codon bias in mitochondrial protein genes.
- Codon bias patterns suggest evolutionary adaptations in different lineages.
Takeaway
Different species have different preferences for how they use the building blocks of proteins, which can help them adapt and evolve.
Methodology
The study compared genome-wide codon bias in six species by analyzing their protein coding sequences and exploring relationships between codon bias and protein function.
Potential Biases
Potential bias in the selection of genes for analysis and the interpretation of codon bias.
Limitations
The study may contain false positives in identifying orthologs due to the relaxed criteria used.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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