Effects of Marine Nutraceuticals on Inflammation in Skin Cells
Author Information
Author(s): Muthusamy Visalini, Hodges Lynn D., Macrides Theodore A., Boyle Glen M., Piva Terrence J.
Primary Institution: RMIT University
Hypothesis
The study investigates the effects of novel marine nutraceuticals on the release of TNF-α from UVB-irradiated human melanocyte-derived cells.
Conclusion
The marine nutraceuticals significantly reduced TNF-α levels in UVB-irradiated human melanocyte-derived cells.
Supporting Evidence
- TNF-α levels fell by 53%, 65%, and 76% with α-tocopherol, CO2-SFE mussel oil, and 5β-scymnol, respectively.
- UVB radiation increased TNF-α release significantly when IL-1α was added.
- The compounds did not inhibit the p38 MAPK pathway despite reducing TNF-α levels.
Takeaway
This study found that certain marine products can help reduce inflammation in skin cells caused by UV light.
Methodology
Human melanocyte-derived cells were exposed to UVB radiation and treated with marine nutraceuticals to measure TNF-α levels.
Limitations
The study primarily focused on in vitro conditions, which may not fully replicate in vivo responses.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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