Prophylactic Antibiotic Treatment in Experimental Necrotising Pancreatitis
Author Information
Author(s): Fritz Stefan, Hartwig Werner, Lehmann Ronny, Will-Schweiger Katja, Kommerell Mechthild, Hackert Thilo, Schneider Lutz, Büchler Markus W, Werner Jens
Primary Institution: University of Heidelberg
Hypothesis
Is prophylactic antibiotic treatment more effective than on-demand therapy in preventing complications in experimental necrotising pancreatitis?
Conclusion
Prophylactic antibiotic treatment significantly reduces pancreatic superinfection, bacteraemia, and mortality compared to on-demand treatment.
Supporting Evidence
- Without antibiotic treatment, pancreatic superinfection was observed in almost all cases.
- Prophylactic treatment reduced mortality to 0% compared to 42.9% in controls.
- Therapeutic administration reduced mortality to 27.3%.
Takeaway
Giving antibiotics early helps sick rats with pancreatitis not get infections and survive better than waiting to give them antibiotics.
Methodology
Inbred male Wistar rats were used to compare prophylactic versus on-demand antibiotic treatment in a controlled experimental model of necrotising pancreatitis.
Potential Biases
Potential bias due to the limited number of animals and the controlled experimental setting.
Limitations
The study was conducted in a controlled animal model, which may not fully replicate human conditions.
Participant Demographics
Inbred male Wistar rats weighing 300 to 340 g.
Statistical Information
P-Value
p = 0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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