Maternal Celiac Disease Autoantibodies and Placental Function
Author Information
Author(s): Anjum Naheed, Baker Philip N, Robinson Nicola J, Aplin John D
Primary Institution: University of Manchester
Hypothesis
Do maternal celiac disease autoantibodies affect placental function?
Conclusion
Maternal celiac disease may compromise placental function due to the binding of autoantibodies.
Supporting Evidence
- Celiac disease occurs in about 1 in 80 pregnant women.
- IgA autoantibodies from celiac disease serum bind significantly more to the placenta than control sera.
- Direct binding assays showed that maternal autoantibodies inhibit placental transglutaminase activity.
Takeaway
Moms with celiac disease can have antibodies that stick to the placenta and might make it not work as well.
Methodology
ELISA and immunohistochemistry were used to study the binding of autoantibodies to placental tissue.
Potential Biases
Potential bias in serum sample selection and testing methods.
Limitations
The study may not account for all variables affecting placental function in celiac disease.
Participant Demographics
132 serum samples from non-pregnant donors were used.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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