Deep Proteomic Profiling of Kidney Aging and Senescence in Monkeys
Author Information
Author(s): King Christina, Burton Jordan, Schaaf George, Kritchevsky Stephen, Cline J, Justice Jamie, Quillen Ellen, Schilling Birgit
Primary Institution: Buck Institute for Research on Aging
Hypothesis
How does ionizing radiation exposure drive renal aging processes?
Conclusion
Ionizing radiation exposure significantly alters protein expression in the kidneys, suggesting a potential link between radiation and kidney aging.
Supporting Evidence
- Over 75% of significantly-altered proteins are significantly upregulated.
- Proteins associated with kidney disease among irradiated animals are related to EGF pathways, integrin signaling, and fibrosis.
- Significantly-altered proteins related to irradiation exposure are involved in fibrosis.
Takeaway
This study looked at how radiation affects the kidneys in monkeys, finding that many proteins change when they are exposed to radiation, which might make their kidneys age faster.
Methodology
Quantitative proteomics was used to analyze kidney cortex tissues from non-human primates exposed to radiation.
Participant Demographics
Non-human primates (Macaca mulatta) from the Wake Forest Non-Human Primate Radiation Late Effects Cohort.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website