Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis
2008
Evolution and Function of Fungal Siderophore Synthetases
Sample size: 49
publication
Evidence: moderate
Author Information
Author(s): Bushley Kathryn E, Ripoll Daniel R, Turgeon B Gillian
Primary Institution: Cornell University
Hypothesis
Are there distinct lineages of ferrichrome synthetases in fungi?
Conclusion
Ferrichrome synthetases are restricted to certain fungi and evolved through domain loss and duplication.
Supporting Evidence
- All filamentous ascomycetes queried contained at least one ferrichrome synthetase.
- Phylogenetic analyses suggest that ferrichrome synthetases derive from an ancestral hexamodular gene.
- Key residues in the adenylation domain pocket were identified as important for substrate choice.
Takeaway
Some fungi make special proteins to help them get iron from their environment, and these proteins have changed over time.
Methodology
Phylogenetic analysis of fungal genomes and protein modeling.
Limitations
The absence of certain genes in some fungi may be due to incomplete genome sequences.
Digital Object Identifier (DOI)
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