Study Protocol for Red Cell Transfusion in Stem Cell Transplantation
Author Information
Author(s): Tay Jason, Tinmouth Alan, Fergusson Dean, Allan David
Primary Institution: The Ottawa Hospital Blood and Marrow Programme, The Ottawa Hospital, Ottawa, Canada
Hypothesis
Does a restrictive red cell transfusion strategy improve outcomes compared to a liberal strategy in patients undergoing hematopoietic stem cell transplantation?
Conclusion
This pilot trial will provide preliminary insight into red cell transfusion practices and their influence on outcomes in hematopoietic stem cell transplantation.
Supporting Evidence
- Red blood cell transfusion can be life-saving but may not always provide significant clinical benefits.
- Observational studies have linked red blood cell transfusions to increased morbidity and mortality.
- This study aims to clarify the role of red cell transfusion in HSCT outcomes.
Takeaway
This study is trying to find out if giving less blood during stem cell transplants is just as safe as giving more blood.
Methodology
A randomized pilot study comparing restrictive and liberal red cell transfusion strategies in patients undergoing HSCT.
Potential Biases
Potential bias in participant selection and adherence to transfusion protocols.
Limitations
As a pilot study, it may not provide definitive answers and is primarily focused on feasibility.
Participant Demographics
Adult patients undergoing either autologous or allogeneic HSCT from 3 Canadian centers.
Digital Object Identifier (DOI)
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