Changes in Antimicrobial Resistance among Salmonella enterica Serovar Typhimurium
Author Information
Author(s): Margaret A. Davis, Dale D. Hancock, Thomas E. Besser, Daniel H. Rice, John M. Gay, Clive Gay, Lynne Gearhart, Ronald DiGiacomo
Primary Institution: Washington State University
Hypothesis
How do antimicrobial resistance patterns of Salmonella enterica serovar Typhimurium from human and cattle sources relate to antimicrobial use in livestock and humans?
Conclusion
The study found significant changes in antimicrobial resistance patterns in Salmonella Typhimurium isolates from both humans and cattle over a 15-year period.
Supporting Evidence
- Resistance to chloramphenicol increased significantly in both cattle and human isolates by the mid-1990s.
- 79% of isolates from cattle were resistant to ampicillin, streptomycin, tetracycline, and sulfonamides throughout the study period.
- Isolates with the ACSSuT resistance pattern increased in frequency over the study period.
Takeaway
This study looked at how germs from cows and people became resistant to medicines over time, showing that some germs are getting stronger and harder to treat.
Methodology
The study compared antimicrobial resistance patterns of Salmonella Typhimurium isolates from human and cattle sources over a 15-year period using clinical samples and susceptibility testing.
Limitations
The study may not account for all factors influencing antimicrobial resistance, and data on some isolates were not available.
Participant Demographics
Isolates were obtained from human clinical specimens and clinical bovine samples in the Pacific Northwest.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
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