Parallel Synthesis of an Imidazole-4,5-dicarboxamide Library Bearing Amino Acid Esters and Alkanamines
2008
Synthesis of Imidazole-4,5-dicarboxamide Library
Sample size: 126
publication
Evidence: moderate
Author Information
Author(s): Rosanna Solinas, John C. DiCesare, Paul W. Baures
Primary Institution: The University of Tulsa
Hypothesis
The imidazole-4,5-dicarboxylic acid scaffold can be modified to create potential kinase inhibitors.
Conclusion
A library of 126 imidazole-4,5-dicarboxamides was successfully synthesized and characterized, showing potential for biological activity.
Supporting Evidence
- All library members were submitted to the Molecular Library Small Molecule Repository for screening.
- The compounds showed bioactivity against calpain II and in cell-based assays.
- The library members were characterized by LC-MS and NMR spectroscopy.
Takeaway
Scientists made a big collection of new compounds that might help in treating diseases by blocking certain proteins in our cells.
Methodology
The compounds were synthesized using parallel synthesis and characterized by LC-MS and NMR spectroscopy.
Limitations
The study did not quantify the level of impurities in the crude reactions.
Digital Object Identifier (DOI)
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