The Potential Interplay of Adipokines with Toll-Like Receptors in the Development of Hepatocellular Carcinoma
2011
The Role of Adipokines and Toll-Like Receptors in Liver Cancer Development
publication
Evidence: moderate
Author Information
Author(s): Wang Shen-Nien, Wang Sen-Te, Lee King Teh
Primary Institution: Kaohsiung Medical University
Hypothesis
The interplay between adipokines and Toll-like receptors (TLRs) contributes to the development of hepatocellular carcinoma (HCC).
Conclusion
Adipokines and TLRs are crucial links between chronic inflammation and the development of HCC.
Supporting Evidence
- Obesity is linked to chronic inflammation, which can lead to liver cancer.
- Adipokines can influence immune responses and inflammation in the liver.
- TLRs are involved in the immune response and have been implicated in cancer development.
Takeaway
This study looks at how fat-related proteins and immune receptors in the body can work together to cause liver cancer, especially in people who are overweight.
Methodology
The paper reviews existing studies on the roles of TLRs and adipokines in inflammation and cancer development.
Limitations
The study primarily relies on existing literature and does not present new experimental data.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website