Smoking Related Cancers and Loci at Chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish Population

2011

Genetic Factors Linked to Smoking-Related Cancers in the Polish Population

Sample size: 1742 publication 10 minutes Evidence: moderate

Author Information

Author(s): Jaworowska Ewa, Trubicka Joanna, Lener Marcin R., Masojć Bartłomiej, Złowocka-Perłowska Elżbieta, McKay James D., Renard Hélène, Oszutowska Dorota, Wokołorczyk Dominika, Lubiński Jakub, Grodzki Tomasz, Serwatowski Piotr, Nej-Wołosiak Katarzyna, Tołoczko-Grabarek Aleksandra, Sikorski Andrzej, Słojewski Marcin, Jakubowska Anna, Cybulski Cezary, Lubiński Jan, Scott Rodney J.

Primary Institution: Pomeranian Medical University, Szczecin, Poland

Hypothesis

Are specific genetic loci associated with the risk of smoking-related cancers in the Polish population?

Conclusion

The study found that certain genetic loci are associated with lung cancer risk but not with bladder or laryngeal cancer in the Polish population.

Supporting Evidence

Two SNPs on chromosome 15q25 were strongly associated with lung cancer.
The adjusted odds ratio for carrying the rare allele of rs402710 was 0.77.
None of the other regions analyzed were implicated in the risk of bladder or laryngeal cancer.
The study had 80% power to detect minimum odds ratios in the range of 1.3–1.5 for lung cancer.

Takeaway

This study looked at how certain genes might make people more likely to get lung cancer from smoking, but it didn't find the same link for bladder or throat cancers.