Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter
2011
Human Teneurin-1 and Its Regulation by EMX2
publication
Evidence: high
Author Information
Author(s): Jan Beckmann, Antonio Vitobello, Jacqueline Ferralli, Daniela Kenzelmann Brož, Filippo M. Rijli, Ruth Chiquet-Ehrismann
Primary Institution: Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation
Hypothesis
Is EMX2 a direct regulator of human teneurin-1 expression?
Conclusion
Human teneurin-1 is directly regulated by EMX2 at a newly identified promoter region.
Supporting Evidence
- EMX2 directly binds to the newly identified promoter element of human teneurin-1.
- The expression of teneurin-1 correlates with EMX2 expression in the developing brain.
- Mutations in the EMX2 binding site significantly reduce promoter activity.
Takeaway
This study found that a protein called EMX2 helps control the expression of another protein called teneurin-1, which is important for brain development.
Methodology
The study used 5' RACE, reporter gene assays, and in vivo electroporation in chick embryos to investigate the regulation of teneurin-1 by EMX2.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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