Understanding the Human Interactome and Tissue-Specific Functions
Author Information
Author(s): Souiai Ouissem, Becker Emmanuelle, Prieto Carlos, Benkahla Alia, De Las Rivas Javier, Brun Christine
Primary Institution: INSERM, U928, TAGC, Marseille, France
Hypothesis
Is tissue-specificity encoded within the interactome?
Conclusion
The functional organization of the human interactome reflects several integrative levels of functions, with housekeeping and regulatory tissue-specific functions at the center and physiological tissue-specific functions at the periphery.
Supporting Evidence
- The study identified a Largest Common Interactome Network (LCIN) that represents a functional interactome core.
- Tissue-specific interactions are categorized into regulatory, developmental, and physiological functions.
- Housekeeping functions are centrally located in the interactome, while physiological functions are found at the periphery.
Takeaway
This study looks at how proteins interact in different tissues and finds that some interactions are common across all tissues while others are specific to certain tissues.
Methodology
The study combined protein-protein interactions, expression data, functional annotations, and interactome topology to analyze tissue-specific interactions.
Potential Biases
Potential bias due to reliance on specific datasets for protein interactions and expression.
Limitations
The study relies on expression data from ESTs, which may not capture all tissue-specific interactions.
Participant Demographics
Human proteins and tissues were analyzed.
Statistical Information
P-Value
p<10−5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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