YKL-40's Role in Mammary Cell Development
Author Information
Author(s): Scully Steve, Yan Wei, Bentley Brooke, Cao Qing Jackie, Shao Rong
Primary Institution: Pioneer Valley Life Sciences Institute, University of Massachusetts, Springfield, Massachusetts, United States of America
Hypothesis
YKL-40 inhibits mammary epithelial differentiation and development during mammary gland development.
Conclusion
YKL-40 inhibits mammary epithelial secretion and differentiation, impairs epithelial polarization, and facilitates cell motility in the presence of lactogenic hormones.
Supporting Evidence
- YKL-40 was expressed exclusively by ductal epithelial cells of parous and non-parous mammary tissue.
- Treatment with recombinant YKL-40 significantly inhibited acinar formation, luminal polarization, and secretion.
- YKL-40 increased cell motility and suppressed expression of E-cadherin.
Takeaway
YKL-40 is a protein that stops mammary cells from growing and working properly when certain hormones are present, which is important for understanding how breast tissue changes.
Methodology
The study used a 3-D Matrigel culture system to analyze the effects of YKL-40 on mammary epithelial cells in the presence of lactogenic hormones.
Limitations
The study does not explore the long-term effects of YKL-40 on mammary tissue or its role in cancer progression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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