Antipsychotics for Treating Behavioral and Psychological Symptoms of Dementia
Author Information
Author(s): Liperoti Rosa, Pedone Claudio, Corsonello Andrea
Primary Institution: Università Cattolica del Sacro Cuore
Hypothesis
What is the efficacy and safety of antipsychotics in treating behavioral and psychological symptoms of dementia?
Conclusion
Antipsychotics may provide some benefits for treating behavioral and psychological symptoms of dementia, but their use is associated with significant risks.
Supporting Evidence
- Up to 90% of Alzheimer's patients may experience behavioral and psychological symptoms.
- Antipsychotics have been used for decades, but newer compounds promise fewer side effects.
- Evidence suggests that both risperidone and olanzapine may reduce aggression.
Takeaway
This study looks at how certain medications can help people with dementia who are acting out or feeling very upset. But these medicines can also cause serious problems.
Methodology
The review summarizes the pathophysiology and neuropharmacology of BPSD and discusses the efficacy and safety of antipsychotics.
Potential Biases
Potential bias due to the retrospective nature of some studies and the high placebo response rates.
Limitations
Limited evidence supports the use of antipsychotics for dementia, and many studies had small sample sizes.
Participant Demographics
Patients with dementia, including Alzheimer's disease and other types.
Digital Object Identifier (DOI)
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