Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
2009
NMDA Receptor NR2B Subunit's Role in Memory and Chronic Pain
publication
Evidence: moderate
Author Information
Author(s): Zhuo Min
Primary Institution: University of Toronto
Hypothesis
The NR2B subunit of NMDA receptors plays distinct roles in learning and chronic pain.
Conclusion
The study suggests that NR2B-containing NMDA receptors are crucial for chronic pain but do not significantly affect memory storage.
Supporting Evidence
- NR2B receptors are important for chronic pain but not for memory storage.
- Studies show that NR2B receptor antagonists can reduce chronic pain.
- Genetic studies indicate that NR2B overexpression enhances chronic pain responses.
Takeaway
This study looks at how a part of a brain receptor, called NR2B, helps us learn and feel pain. It finds that while it helps with pain, it doesn't really help us remember things.
Methodology
The review examines existing literature on NMDA receptor NR2B subunit's roles in learning and chronic pain.
Limitations
The review is based on existing studies and may not cover all aspects of NMDA receptor functions.
Digital Object Identifier (DOI)
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