Previous Renal Replacement Therapy Time at Start of Peritoneal Dialysis Independently Impact on Peritoneal Membrane Ultrafiltration Failure

2011

Impact of Previous Renal Replacement Therapy on Peritoneal Dialysis Success

Sample size: 123 publication 10 minutes Evidence: moderate

Author Information

Author(s): Oliveira Luís, Rodrigues Anabela

Primary Institution: Nephrology Department, CHP-Hospital Santo António, Porto, Portugal

Hypothesis

Previous renal replacement therapy time and residual renal function at start of peritoneal dialysis impact on ultrafiltration failure.

Conclusion

Lower residual renal function and longer previous renal replacement therapy time are associated with a higher risk of ultrafiltration failure in peritoneal dialysis patients.

Supporting Evidence

UFF-free survival was 97%, 87%, and 83% at 1, 3, and 5 years, respectively.
Baseline lower RRF and longer previous RRT were independently associated with lower UFF-free survival.
CA125 levels decreased significantly during follow-up.

Takeaway

If someone has been on kidney treatment for a long time before starting peritoneal dialysis, they might have more trouble with fluid removal later on.

Methodology

The study followed 123 patients for a median of 26 months, analyzing various clinical parameters and their impact on ultrafiltration failure using mixed linear models and Cox multivariate analysis.