How E-selectin helps colon cancer cells survive
Author Information
Author(s): Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric Paquet, Jacques Huot
Primary Institution: Le Centre de recherche en cancérologie de l'Université Laval et Centre de recherche du CHUQ
Hypothesis
E-selectin activation of Death receptor-3 enhances colon cancer cell survival through the PI3K-NFκB pathway.
Conclusion
E-selectin activation of DR3 leads to increased survival of colon cancer cells by activating the PI3K/NFκB pathway.
Supporting Evidence
- E-selectin interacts with Death receptor-3 on colon cancer cells.
- Activation of the PI3K/Akt pathway was observed following E-selectin treatment.
- Inhibition of PI3K increased apoptosis in colon cancer cells treated with E-selectin.
- Metastatic colon cancer cells express a splice variant of DR3 that lacks a death domain.
Takeaway
E-selectin helps colon cancer cells stick to blood vessels and survive by turning on a special survival signal inside the cells.
Methodology
The study used cell survival assays, apoptosis assays, and PCR to investigate the effects of E-selectin on colon cancer cells.
Limitations
The study primarily focuses on specific colon cancer cell lines and may not represent all colon cancer types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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