Unconventional Use of LC3 by Coronaviruses through the Alleged Subversion of the ERAD Tuning Pathway
2011
How Coronaviruses Use Host Cell Mechanisms for Replication
publication
Evidence: moderate
Author Information
Author(s): Reggiori Fulvio, de Haan Cornelis A.M., Molinari Maurizio
Primary Institution: University Medical Center Utrecht
Hypothesis
Coronaviruses co-opt membranous carriers from the endoplasmic reticulum for their replication.
Conclusion
Coronaviruses hijack the ERAD tuning pathway to facilitate their replication by utilizing EDEMosomes.
Supporting Evidence
- Coronaviruses utilize EDEMosomes, which are vesicles that transport ERAD factors for degradation.
- LC3-I is involved in the formation of both EDEMosomes and CoV-induced DMVs.
- CoV replication is supported by hijacking the ERAD tuning pathway.
Takeaway
Coronaviruses are sneaky and use parts of our cells to help them make more viruses. They take advantage of a system that usually helps get rid of bad proteins.
Methodology
The study reviews recent data and models on how coronaviruses hijack cellular mechanisms for their replication.
Limitations
The exact molecular principles of the biogenesis of EDEMosomes and DMVs remain poorly understood.
Digital Object Identifier (DOI)
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