Regulation of Cytochrome P450 in Human Tumors
Author Information
Author(s): G. Smith, D.J. Harrison, N. East, F. Rae, H. Wolf, C.R. Wolf
Primary Institution: Imperial Cancer Research Fund
Hypothesis
How do environmental and hormonal factors regulate the expression of human cytochrome P450 enzymes?
Conclusion
Human breast and colon tumors can express cytochrome P450 enzymes, and their levels can be influenced by environmental agents.
Supporting Evidence
- Human tumors express cytochrome P450 enzymes constitutively.
- Environmental agents can modulate P450 levels in human tumors.
- TCPOBOP and dexamethasone significantly induce P450 expression in tumors.
Takeaway
Scientists studied how certain chemicals can change the way human tumors process drugs. They found that these tumors can react to these chemicals just like normal human cells.
Methodology
Human tumors were grown as xenografts in immune deficient mice and treated with various compounds to observe changes in cytochrome P450 expression.
Limitations
The influence of the mouse host on the results cannot be ruled out.
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