PGC-1alpha as modifier of onset age in Huntington disease
2009
PGC-1alpha and Huntington Disease Onset Age
Sample size: 400
publication
Evidence: moderate
Author Information
Author(s): Taherzadeh-Fard Elahe, Saft Carsten, Andrich Jürgen, Wieczorek Stefan, Arning Larissa
Primary Institution: Ruhr-University
Hypothesis
Does the PGC-1alpha gene influence the age of onset in Huntington disease?
Conclusion
The PGC-1alpha gene has modifying effects on the age of onset in Huntington disease.
Supporting Evidence
- The study involved over 400 Huntington disease patients.
- A specific polymorphism in the PGC-1alpha gene was linked to age of onset.
- The mean age of onset varied between different genotypes.
Takeaway
This study found that a specific gene can change how early people get symptoms of Huntington disease.
Methodology
The study analyzed polymorphisms in the PGC-1alpha gene in over 400 Huntington disease patients.
Limitations
The study only included a German cohort, which may limit generalizability.
Participant Demographics
The cohort consisted of more than 400 unrelated Huntington disease patients from Germany.
Statistical Information
P-Value
< 0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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