IL23R Gene and Its Association with Inflammatory Diseases
Author Information
Author(s): Einarsdottir Elisabet, Koskinen Lotta LE, Dukes Emma, Kainu Kati, Suomela Sari, Lappalainen Maarit, Ziberna Fabiana, Korponay-Szabo Ilma R, Kurppa Kalle, Kaukinen Katri, Ádány Róza, Pocsai Zsuzsa, Széles György, Färkkilä Martti, Turunen Ulla, Halme Leena, Paavola-Sakki Paulina, Not Tarcisio, Vatta Serena, Ventura Alessandro, Löfberg Robert, Torkvist Leif, Bresso Francesca, Halfvarson Jonas, Mäki Markku, Kontula Kimmo, Saarialho-Kere Ulpu, Kere Juha, D'Amato Mauro, Saavalainen Päivi
Primary Institution: University of Helsinki
Hypothesis
The study hypothesized that SNPs in the IL23R region might also play a role in celiac disease.
Conclusion
The study found a significant association of IL23R with Crohn's disease and ulcerative colitis in Swedish patients, and linkage to psoriasis in the Finnish population, but no association with celiac disease in Finnish, Hungarian, or Italian samples.
Supporting Evidence
- IL23R was associated with Crohn's disease and ulcerative colitis in Swedish patients.
- Linkage of IL23R to psoriasis was found in the Finnish population.
- No association of IL23R variants with celiac disease was found in Finnish, Hungarian, or Italian samples.
Takeaway
Researchers looked at a gene called IL23R to see if it was linked to diseases like Crohn's disease, ulcerative colitis, psoriasis, and celiac disease. They found it was linked to some of these diseases but not to celiac disease.
Methodology
The study involved genetic association analysis of IL23R SNPs in various patient populations with IBD, psoriasis, and celiac disease.
Limitations
The study did not find significant associations in the Hungarian and Italian populations for celiac disease, indicating potential population-specific genetic factors.
Participant Demographics
The study included Swedish, Finnish, Hungarian, and Italian populations with varying sample sizes for each disease.
Statistical Information
P-Value
p = 0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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