Graft-versus-lymphoma effect in a 64-year-old woman after stem-cell transplantation
Author Information
Author(s): Gerhard Behre, Thomas Weber, Sebastian Theurich, Maximilian Christopeit
Primary Institution: Department of Internal Medicine IV, Oncology and Hematology, Martin-Luther-University Halle-Wittenberg
Hypothesis
Can a graft-versus-lymphoma effect be identified in a patient after allogeneic stem-cell transplantation?
Conclusion
The study identified an allogeneic graft reaction against progressive lymphoma, which influenced treatment decisions.
Supporting Evidence
- The patient received a peripheral blood-stem-cell graft from her HLA-identical sister.
- The study highlights the importance of differential diagnosis in post-transplant erythema.
- Histology showed both lymphoma and graft versus lymphoma in the skin biopsy.
Takeaway
This study shows that a special immune response can help fight lymphoma in a patient who received a stem-cell transplant.
Methodology
The case involved a 64-year-old woman who received a stem-cell transplant and underwent various treatments while monitoring for graft-versus-host disease and lymphoma progression.
Limitations
The patient ultimately died from multiple organ failure, which limits the conclusions that can be drawn about the long-term effectiveness of the treatments.
Participant Demographics
64-year-old Caucasian woman
Digital Object Identifier (DOI)
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