Effects of Ganoderma lucidum Polysaccharide on Dendritic Cells in Asthmatic Children
Author Information
Author(s): Jan Rong-Hwa, Lin Teng-Yi, Hsu Ya-Chun, Lee Shiuh-Sheng, Lo Shih-Yen, Chang Mingi, Chen Li-Kuang, Lin Yu-Li
Primary Institution: Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan
Hypothesis
The study aimed to clarify the immunologic effect of Ganoderma lucidum-derived polysaccharide on monocyte-derived dendritic cells from asthmatic children allergic to house dust mites.
Conclusion
The presence of Ganoderma lucidum polysaccharide promoted allergic dendritic cells to produce pro-Th1 cytokines and shifted the immune balance towards Th1 in children with allergic asthma.
Supporting Evidence
- PS-G increased the expression of maturation markers on dendritic cells.
- Dendritic cells treated with PS-G produced higher levels of pro-Th1 cytokines.
- The addition of PS-G to allergen-pulsed dendritic cells enhanced T-cell proliferation.
Takeaway
A mushroom extract helped immune cells in kids with asthma to fight allergies better by changing how they respond to allergens.
Methodology
Monocyte-derived dendritic cells from asthmatic children were stimulated with Der p 1 allergen in the presence or absence of Ganoderma lucidum polysaccharide, and various cytokines were measured.
Potential Biases
Potential bias due to the specific population studied (children with allergic asthma) may limit generalizability.
Limitations
The study focused only on a small sample size of children with allergic asthma.
Participant Demographics
Children with allergic asthma sensitive to Dermatophagoides pteronyssinus.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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